Unrecognized vitamin D3 deficiency is common in Parkinson disease
Identifieur interne : 000C30 ( Main/Exploration ); précédent : 000C29; suivant : 000C31Unrecognized vitamin D3 deficiency is common in Parkinson disease
Auteurs : Hongliu Ding ; Kaltra Dhima ; Kaitlin C. Lockhart ; Joseph J. Locascio ; Ashley N. Hoesing ; Karen Duong ; Ana Trisini-Lipsanopoulos ; Michael T. Hayes ; U. Shivraj Sohur ; Anne-Marie Wills ; Brit Mollenhauer ; Alice W. Flaherty ; Albert Y. Hung ; Nicte Mejia ; Vikram Khurana ; Stephen N. Gomperts ; Dennis J. Selkoe ; Michael A. Schwarzschild ; Michael G. Schlossmacher ; Bradley T. Hyman ; Lewis R. Sudarsky ; John H. Growdon ; Clemens R. ScherzerSource :
- Neurology [ 0028-3878 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Biomarkers (metabolism), Case-Control Studies, Cholecalciferol (deficiency), Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease (etiology), Parkinson Disease (metabolism), Prevalence, Severity of Illness Index, Vitamin D Deficiency (complications), Vitamin D Deficiency (diagnosis).
- MESH :
- chemical , deficiency : Cholecalciferol.
- chemical , metabolism : Biomarkers.
- complications : Vitamin D Deficiency.
- diagnosis : Vitamin D Deficiency.
- etiology : Parkinson Disease.
- metabolism : Parkinson Disease.
- Aged, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prevalence, Severity of Illness Index.
Abstract
To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D3, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD).
We used liquid chromatography/tandem mass spectrometry to establish an association specifically between deficiency of 25-hydroxy-vitamin D3 and PD in a cross-sectional and longitudinal case-control study of 388 patients (mean Hoehn and Yahr stage of 2.1 ± 0.6) and 283 control subjects free of neurologic disease nested in the Harvard Biomarker Study.
Plasma levels of 25-hydroxy-vitamin D3 were associated with PD in both univariate and multivariate analyses with
Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D–deficient. This finding has immediate relevance for individual patients at risk of falls as well as public health, and warrants further investigation into the mechanism underlying this association.
Url:
DOI: 10.1212/WNL.0b013e3182a95818
PubMed: 24068787
PubMed Central: 3888173
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000642
- to stream Pmc, to step Curation: 000642
- to stream Pmc, to step Checkpoint: 000557
- to stream PubMed, to step Corpus: 000850
- to stream PubMed, to step Curation: 000850
- to stream PubMed, to step Checkpoint: 000850
- to stream Ncbi, to step Merge: 001571
- to stream Ncbi, to step Curation: 001571
- to stream Ncbi, to step Checkpoint: 001571
- to stream Main, to step Merge: 000C35
- to stream Main, to step Curation: 000C30
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Unrecognized vitamin D<sub>3</sub> deficiency is common in Parkinson disease</title><author><name sortKey="Ding, Hongliu" sort="Ding, Hongliu" uniqKey="Ding H" first="Hongliu" last="Ding">Hongliu Ding</name></author><author><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name></author><author><name sortKey="Lockhart, Kaitlin C" sort="Lockhart, Kaitlin C" uniqKey="Lockhart K" first="Kaitlin C." last="Lockhart">Kaitlin C. Lockhart</name></author><author><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name></author><author><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name></author><author><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name></author><author><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name></author><author><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T." last="Hayes">Michael T. Hayes</name></author><author><name sortKey="Sohur, U Shivraj" sort="Sohur, U Shivraj" uniqKey="Sohur U" first="U. Shivraj" last="Sohur">U. Shivraj Sohur</name></author><author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name></author><author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name></author><author><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name></author><author><name sortKey="Mejia, Nicte" sort="Mejia, Nicte" uniqKey="Mejia N" first="Nicte" last="Mejia">Nicte Mejia</name></author><author><name sortKey="Khurana, Vikram" sort="Khurana, Vikram" uniqKey="Khurana V" first="Vikram" last="Khurana">Vikram Khurana</name></author><author><name sortKey="Gomperts, Stephen N" sort="Gomperts, Stephen N" uniqKey="Gomperts S" first="Stephen N." last="Gomperts">Stephen N. Gomperts</name></author><author><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name></author><author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name></author><author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name></author><author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name></author><author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24068787</idno><idno type="pmc">3888173</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888173</idno><idno type="RBID">PMC:3888173</idno><idno type="doi">10.1212/WNL.0b013e3182a95818</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000642</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000642</idno><idno type="wicri:Area/Pmc/Curation">000642</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000642</idno><idno type="wicri:Area/Pmc/Checkpoint">000557</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000557</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000850</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000850</idno><idno type="wicri:Area/PubMed/Curation">000850</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000850</idno><idno type="wicri:Area/PubMed/Checkpoint">000850</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000850</idno><idno type="wicri:Area/Ncbi/Merge">001571</idno><idno type="wicri:Area/Ncbi/Curation">001571</idno><idno type="wicri:Area/Ncbi/Checkpoint">001571</idno><idno type="wicri:doubleKey">0028-3878:2013:Ding H:unrecognized:vitamin:d</idno><idno type="wicri:Area/Main/Merge">000C35</idno><idno type="wicri:Area/Main/Curation">000C30</idno><idno type="wicri:Area/Main/Exploration">000C30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Unrecognized vitamin D<sub>3</sub> deficiency is common in Parkinson disease</title><author><name sortKey="Ding, Hongliu" sort="Ding, Hongliu" uniqKey="Ding H" first="Hongliu" last="Ding">Hongliu Ding</name></author><author><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name></author><author><name sortKey="Lockhart, Kaitlin C" sort="Lockhart, Kaitlin C" uniqKey="Lockhart K" first="Kaitlin C." last="Lockhart">Kaitlin C. Lockhart</name></author><author><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name></author><author><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name></author><author><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name></author><author><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name></author><author><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T." last="Hayes">Michael T. Hayes</name></author><author><name sortKey="Sohur, U Shivraj" sort="Sohur, U Shivraj" uniqKey="Sohur U" first="U. Shivraj" last="Sohur">U. Shivraj Sohur</name></author><author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name></author><author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name></author><author><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name></author><author><name sortKey="Mejia, Nicte" sort="Mejia, Nicte" uniqKey="Mejia N" first="Nicte" last="Mejia">Nicte Mejia</name></author><author><name sortKey="Khurana, Vikram" sort="Khurana, Vikram" uniqKey="Khurana V" first="Vikram" last="Khurana">Vikram Khurana</name></author><author><name sortKey="Gomperts, Stephen N" sort="Gomperts, Stephen N" uniqKey="Gomperts S" first="Stephen N." last="Gomperts">Stephen N. Gomperts</name></author><author><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name></author><author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name></author><author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name></author><author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name></author><author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Biomarkers (metabolism)</term><term>Case-Control Studies</term><term>Cholecalciferol (deficiency)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (metabolism)</term><term>Prevalence</term><term>Severity of Illness Index</term><term>Vitamin D Deficiency (complications)</term><term>Vitamin D Deficiency (diagnosis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Cholecalciferol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Vitamin D Deficiency</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Vitamin D Deficiency</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D<sub>3</sub>, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD).</p></sec><sec><title>Methods:</title><p>We used liquid chromatography/tandem mass spectrometry to establish an association specifically between deficiency of 25-hydroxy-vitamin D<sub>3</sub> and PD in a cross-sectional and longitudinal case-control study of 388 patients (mean Hoehn and Yahr stage of 2.1 ± 0.6) and 283 control subjects free of neurologic disease nested in the Harvard Biomarker Study.</p></sec><sec><title>Results:</title><p>Plasma levels of 25-hydroxy-vitamin D<sub>3</sub> were associated with PD in both univariate and multivariate analyses with <italic>p</italic> values = 0.0034 and 0.047, respectively. Total 25-hydroxy-vitamin D levels, the traditional composite measure of endogenous and exogenous vitamin D, were deficient in 17.6% of patients with PD compared with 9.3% of controls. Low 25-hydroxy-vitamin D<sub>3</sub> as well as total 25-hydroxy-vitamin D levels were correlated with higher total Unified Parkinson’s Disease Rating Scale scores at baseline and during follow-up.</p></sec><sec><title>Conclusions:</title><p>Our study reveals an association between 25-hydroxy-vitamin D<sub>3</sub> and PD and suggests that thousands of patients with PD in North America alone may be vitamin D–deficient. This finding has immediate relevance for individual patients at risk of falls as well as public health, and warrants further investigation into the mechanism underlying this association.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><name sortKey="Ding, Hongliu" sort="Ding, Hongliu" uniqKey="Ding H" first="Hongliu" last="Ding">Hongliu Ding</name><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name><name sortKey="Gomperts, Stephen N" sort="Gomperts, Stephen N" uniqKey="Gomperts S" first="Stephen N." last="Gomperts">Stephen N. Gomperts</name><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T." last="Hayes">Michael T. Hayes</name><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><name sortKey="Khurana, Vikram" sort="Khurana, Vikram" uniqKey="Khurana V" first="Vikram" last="Khurana">Vikram Khurana</name><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name><name sortKey="Lockhart, Kaitlin C" sort="Lockhart, Kaitlin C" uniqKey="Lockhart K" first="Kaitlin C." last="Lockhart">Kaitlin C. Lockhart</name><name sortKey="Mejia, Nicte" sort="Mejia, Nicte" uniqKey="Mejia N" first="Nicte" last="Mejia">Nicte Mejia</name><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name><name sortKey="Sohur, U Shivraj" sort="Sohur, U Shivraj" uniqKey="Sohur U" first="U. Shivraj" last="Sohur">U. Shivraj Sohur</name><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C30 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C30 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3888173
|texte= Unrecognized vitamin D3 deficiency is common in Parkinson disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24068787" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |